Can Priapism Damage be Reversed, while a rare side effect, is something you should be aware of when undergoing treatment for erectile dysfunction (ED) with medications like sildenafil, tadalafil (Cialis), or other PDE5 inhibitors. While it’s not something that most men will experience, it’s important to understand what it is, why it happens, and how to manage it. Priapism is a condition where the penis remains erect for an extended period, typically longer than 4 hours, even without sexual stimulation. It can be painful and may lead to serious complications if not treated promptly. However, it is important to be aware of the risk and know how to recognize the signs, so you can take immediate action if necessary.